- Abihka, Creek Confederacy, Alabama[1]
- Acolapissa (Colapissa), Louisiana and Mississippi[2]
- Ais, eastern coastal Florida[3]
- Alabamalar, Creek Confederacy, Alabama,[1] southwestern Tennessee, northwestern Mississippi[2][4]
- Alafay (Alafia tribe, Pojoy, Pohoy, Costas Alafeyes, Alafaya Costas), Florida[5]
- Amacano, Florida west coast[6]
- Apalachee, northwestern Florida[4]
- Apalachicola, Creek Confederacy, Alabama, Florida, Georgia and South Carolina[1]
- Atakapa (Attacapa), Louisiana west coast and Texas southwestern coast[4]
- Akokisa, Texas southeast coast[1]
- Bidai, Texas southeast coast[1]
- Deadose, eastern Texas
- Eastern Atakapa, western coastal Louisiana
- Orcoquiza, southeast Texas
- Patiri, eastern Texas
- Tlacopsel, southeast Texas
- Avoyel ("little Natchez"), Louisiana[2][7]
- Backhooks Nation (possibly Chuaque, Holpaos, Huaq, Nuaq, Pahoc, Pahor, Paor, Uca),[8] South Carolina
- Bayogoula, southeastern Louisiana[2][7]
- Biloxi, Mississippi[2][4]
- Boca Ratones, Florida
- Caddo Confederacy, Arkansas, Louisiana, Oklahoma, Texas[4][9]
- Adai (Adaizan, Adaizi, Adaise, Adahi, Adaes, Adees, Atayos), Louisiana and Texas[2]
- Cahinnio, southern Arkansas[9]
- Doustioni, north central Louisiana[9]
- Eyeish (Hais), eastern Texas[9]
- Hainai, eastern Texas[9]
- Hasinai, eastern Texas[9]
- Kadohadacho, northeastern Texas, southwestern Arkansas, northwestern Louisiana[9]
- Nabedache, eastern Texas[9]
- Nabiti, eastern Texas[9]
- Nacogdoche, eastern Texas[9]
- Nacono, eastern Texas[9]
- Nadaco, eastern Texas[9]
- Nanatsoho, northeastern Texas[9]
- Nasoni, eastern Texas[9]
- Natchitoches, Lower: central Louisiana, Upper: northeastern Texas[9]
- Neche, eastern Texas[9]
- Nechaui, eastern Texas[9]
- Ouachita, northern Louisiana[9]
- Tula, western Arkansas[9]
- Yatasi, northwestern Louisiana[9]
- Calusa, southwestern Florida[4][5]
- Cape Fear Indians, North Carolina southern coast[2]
- Catawba (Esaw, Usheree, Ushery, Yssa),[8] North Carolina, South Carolina[4]
- Chacato, Florida panhandle and southern Alabama[2]
- Chakchiuma, Alabama and Mississippi[4]
- Chatot (tribe) (Chacato, Chactoo), west Florida
- Chawasha (Washa), Louisiana[2]
- Cheraw (Chara, Charàh), North Carolina
- Çerokiler, Georgia, North Carolina, western tip of South Carolina, Tennessee, Alabama, later Arkansas, Texas, Mexico, and Oklahoma[10]
- Chiaha, Creek Confederacy, Alabama[1]
- Chickahominy, Virginia[11]
- Chickamauga, band of Cherokees in Tennessee and Georgia
- Chickanee (Chiquini), North Carolina
- Çikasovlar, Alabama and Mississippi,[4] later Oklahoma[10]
- Chicora, coastal South Carolina[7]
- Chine, Florida
- Chisca (Cisca), southwestern Virginia, northern Florida[7]
- Chitimacha, Louisiana[4]
- Çoktavlar, Mississippi, Alabama,[4] and parts of Louisiana; later Oklahoma[10]
- Chowanoc, North Carolina
- Krikler, Florida, Georgia, southern Tennessee, Mississippi,[4] later Alabama, Oklahoma[10]
- Congaree (Canggaree), South Carolina[2][12]
- Coree, North Carolina[7]
- Coushatta, Louisiana and Texas
- Coharie, North Carolina
- Cusabo coastal South Carolina[4]
- Eno (people), North Carolina[2]
- Garza, Texas, northern Mexico
- Grigra (Gris), Mississippi[13]
- Guacata (Santalûces), eastern coastal Florida[5]
- Guacozo, Florida
- Guale (Cusabo, Iguaja, Ybaja), coastal Georgia[2][4]
- Guazoco, southwestern Florida coast[5]
- Hitchiti, Creek Confederacy, Georgia, Alabama, and Florida[2]
- Hooks Nation (possibly Chuaque, Huaq, Nuaq),[8] see Backhooks Nation
- Houma, Louisiana and Mississippi[4]
- Jaega, eastern coastal Florida[3]
- Jaupin (Weapemoc), North Carolina
- Jobe (Hobe), part of Jaega, Florida[5]
- Jororo, Florida interior[5]
- Keyauwee, North Carolina[2]
- Koasati, Tennessee[4]
- Koroa, Mississippi[2]
- Luca (tribe), southwestern Florida coast[5]
- Lumbee, North Carolina
- Mabila (Mobile, Movila), northwestern Florida and southern Alabama[4][14]
- Machapunga, North Carolina
- Manahoac, Virginia[15]
- Mattaponi, Virginia
- Matecumbe (Matacumbêses, Matacumbe, Matacombe), Florida Keys[5]
- Mayaca (tribe), Florida[5]
- Mayaimi (Mayami), interior Florida[3]
- Mayajuaca, Florida
- Meherrin, Virginia,[11] North Carolina
- Mikasuki (Miccosukee), Florida
- Mocoso, western Florida[3][5]
- Monaca, Virginia[7]
- Monetons (Monyton, Monekot, Moheton) (Siouan), West Virginia and Virginia
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- Mougoulacha, Mississippi[7]
- Muscogee (Creek), Tennessee, Georgia, Alabama, Mississippi, Florida, later Oklahoma
- Nahyssan, Virginia
- Naniaba, northwestern Florida and southern Alabama[4]
- Nansemond, Virginia[11]
- Natchez, Louisiana and Mississippi[4] later Oklahoma
- Neusiok (Newasiwac, Neuse River Indians), North Carolina[2]
- Norwood culture, Apalachee region, Florida, ca. 12,000 BCE—4500 BCE
- Nottaway, Virginia,[11] North Carolina
- Occaneechi (Siouan), Virginia[11][16]
- Oconee people, Georgia, Florida
- Ofo, Arkansas and Mississippi,[4] eastern Tennessee[2]
- Okchai (Ogchay), central Alabama[2]
- Okelousa, Louisiana[2]
- Opelousas, Louisiana[2]
- Osochee (Oswichee, Usachi, Oosécha), Creek Confederacy, Alabama[1][2]
- Pacara, Florida
- Pakana (Pacâni, Pagna, Pasquenan, Pak-ká-na, Pacanas), central Alabama,[2] later Texas[7]
- Pamlico, North Carolina
- Pamunkey, Virginia[11]
- Pascagoula, Mississippi coast[7]
- Patiri, southeastern Texas
- Pee Dee (Pedee), South Carolina[2][17] and North Carolina
- Pensacola, Florida panhandle and southern Alabama[4]
- Potoskeet, North Carolina
- Quinipissa, southeastern Louisiana and Mississippi[1]
- Rappahannock Tribe, Virginia
- Saluda (Saludee, Saruti), South Carolina[2]
- Santee (Seretee, Sarati, Sati, Sattees), South Carolina (no relation to Santee Sioux), South Carolina[2]
- Santa Luces, Florida
- Saponi, North Carolina,[18] Virginia[11]
- Saura North Carolina
- Sawokli (Sawakola, Sabacola, Sabacôla, Savacola), southern Alabama and Florida panhandle[2]
- Saxapahaw (Sissipahua, Shacioes), North Carolina[2]
- Seminoleler, Florida and Oklahoma[10]
- Sewee (Suye, Joye, Xoye, Soya), South Carolina coast[2]
- Shakori, North Carolina
- Shoccoree, North Carolina,[2] possibly Virginia
- Stegarake, Virginia[15]
- Stuckanox (Stukanox), Virginia[11]
- Sugeree (Sagarees, Sugaws, Sugar, Succa), North Carolina and South Carolina[2]
- Surruque, east central Florida[19]
- Suteree (Sitteree, Sutarees, Sataree), North Carolina
- Taensa, Mississippi[13]
- Talapoosa, Creek Confederacy, Alabama[1]
- Tawasa, Alabama[20]
- Tequesta, southeastern coastal Florida[2][5]
- Terocodame, Texas and Mexico
- Codam
- Hieroquodame
- Oodame
- Perocodame
- Teroodame
- Timucua, Florida and Georgia[2][4][5]
- Acuera, central Florida[21]
- Agua Fresca (or Aqua Dulce or Freshwater), interior northeast Florida[21]
- Arapaha, north central Florida and south central Georgia?[21]
- Cascangue, coastal southeast Georgia[21]
- Icafui (or Icafi), coastal southeast Georgia[21]
- Mocama (or Tacatacuru), coastal northeast Florida and coastal southeast Georgia[21]
- Northern Utina north central Florida[21]
- Ocale, central Florida[21]
- Oconi, interior southeast Georgia[21]
- Potano, north central Florida[21]
- Saturiwa, northeast Florida[21]
- Tucururu (or Tucuru), central? Florida[21]
- Yufera, coastal southeast Georgia[21]
- Yui (or Ibi), coastal southeast Georgia[21]
- Yustaga, north central Florida[21]
- Tiou (Tioux), Mississippi[12]
- Tocaste, Florida[5]
- Tocobaga, Florida[2][5]
- Tohomé, northwestern Florida and southern Alabama[4]
- Tomahitan, eastern Tennessee
- Topachula, Florida
- Tukabatchee (Tuk-ke-bat-che), Creek Confederacy, Alabama[1]
- Tuscarora, North Carolina, Virginia, later New York
- Tuskegee, see Creek
- Tutelo, Virginia[11][16]
- Tunica or (Tonica, Tonnica, and Thonnica), Arkansas and Mississippi[4]
- Uzita, Florida[3][22]
- Vicela, Florida[3]
- Viscaynos, Florida
- Waccamaw, South Carolina
- Wateree (Guatari, Watterees), North Carolina[2]
- Waxhaw (Waxsaws, Wisack, Wisacky, Weesock, Flathead), North Carolina and South Carolina[2][17]
- Westo, Virginia and South Carolina[7]
- Winyaw, South Carolina coast[2]
- Woccon, North Carolina[2][17]
- Yamasee, Florida, Georgia[7]
- Yazoo, southeastern tip of Arkansas, eastern Louisiana, Mississippi[2][23]
- Yuchi (Euchee), central Tennessee,[2][4] later Oklahoma
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