Phillip Allen Sharp

Phillip Allen Sharp
Sharp, 2009
Doğum	6 Haziran 1944 Falmouth, Kentucky
Vatandaşlığı	ABD
Dalı	Biyolog
Çalıştığı yerler	Caltech Cold Spring Harbor Laboratory MIT
Öğrenim	Union College University of Illinois at Urbana-Champaign
Aldığı ödüller	Nobel Fizyoloji veya Tıp Ödülü (1993)

Phillip Allen Sharp (6 Haziran 1944), Amerikan genetikçi ve moleküler biyolog. RNA bağlanmasının kaşiflerinden biridir. Richard J. Roberts ile birlikte ökaryot hücrelerinin DNA dizelerindeki genlerin bitişik sırada olmadığını, aralarda intron denilen okunmayan ve protein sentezine katılmayan bölümlerin olduğunu keşfettiler. Bu sayede mRNA'lar aynı DNA dizesinden bu bölümleri farklı şekilde silmeleri ile farklı proteinleri kodlayabilmektedir. İkili bu keşifleri ile 1993 Nobel Fizyoloji veya Tıp Ödülünü kazanmışlardır.^[1]

Seçilmiş makaleleri

• Petersen C.P., Bordeleau M.E., Pelletier J., Sharp P.A. (17 February 2006). "Short RNAs Repress Translation after Initiation in Mammalian Cells". Mol Cell. 21 (4): 533–42. DOI:10.1016/j.molcel.2006.01.031. PMID 16483934. 

• Cheng C., Sharp P.A. (January 2006). "Regulation of CD44 Alternative Splicing by SRm160 and its Potential Role in Tumor Cell Invasion". Mol Cell Biol. 26 (1): 362–70. DOI:10.1128/MCB.26.1.362-370.2006. PMC 1317625. PMID 16354706. http://mcb.asm.org/cgi/content/full/26/1/362?view=long&pmid=16354706. 

• Tantin D., Schild-Poulter C., Wang V., Hache R.J., Sharp P.A. (1 December 2005). "The Octamer Binding Transcription Factor Oct-1 is a Stress Sensor". Cancer Res. 65 (23): 10750–8. DOI:10.1158/0008-5472.CAN-05-2399. PMID 16322220. 

• Grishok A., Sharp P.A. (29 November 2005). "Negative Regulation of Nuclear Divisions in Caenorhabditis Elegans by Retinoblastoma and RNA Interference-related Genes". Proc Natl Acad Sci U S A. 102 (48): 17360–5. DOI:10.1073/pnas.0508989102. PMC 1297700. PMID 16287966. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1297700. 

• Sharp P.A. (7 October 2005). "1918 Flu and Responsible Science". Science 310 (5745): 17. DOI:10.1126/science.310.5745.17. PMID 16210500. 

• Miskevich F., Doench J.G., Townsend M.T., Sharp P.A., Constantine-Paton M. (15 April 2006). "RNA Interference of Xenopus NMDAR NR1 in vitro and in vivo". J Neurosci Methods 152 (1–2): 65–73. DOI:10.1016/j.jneumeth.2005.08.010. PMID 16182372. 

• Hong J.H., Hwang E.S., McManus M.T., Amsterdam A., Tian Y., Kalmukova R., Mueller E., Benjamin T., Spiegelman B.M., Sharp P.A., Hopkins N., Yaffe M.B. (12 August 2005). "TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation". Science 309 (5737): 1074–8. DOI:10.1126/science.1110955. PMID 16099986. 

• Houbaviy H.B., Dennis L., Jaenisch R., Sharp P.A. (August 2005). "Characterization of a Highly Variable Eutherian microRNA Gene". RNA 11 (8): 1245–57. DOI:10.1261/rna.2890305. PMC 1370808. PMID 15987809. http://www.rnajournal.org/cgi/content/full/11/8/1245. 

• Sharp P.A. (June 2005). "The Discovery of Split Genes and RNA Splicing". Trends Biochem Sci. 30 (6): 279–81. DOI:10.1016/j.tibs.2005.04.002. PMID 15950867. 

• Johnson D.M., Yamaji S., Tennant J., Srai S.K., Sharp P.A. (28 March 2005). "Regulation of Divalent Metal Transporter Expression in Human Intestinal Epithelial Cells Following Exposure to Non-haem Iron". FEBS Lett. 579 (9): 1923–9. DOI:10.1016/j.febslet.2005.02.035. PMID 15792797. 

• Neilson J.R., Sharp P.A. (April 2005). "Herpesviruses Throw a Curve Ball: New Insights into microRNA Biogenesis and Evolution". Nat Methods 2 (4): 252–4. DOI:10.1038/nmeth0405-252. PMID 15782215. 

• Grishok A., Sinskey J.L., Sharp P.A. (15 March 2005). "Transcriptional Silencing of a Transgene by RNAi in the Soma of C. elegans". Genes Dev. 19 (6): 683–96. DOI:10.1101/gad.1247705. PMC 1065722. PMID 15741313. http://www.genesdev.org/cgi/content/full/19/6/683. 

• Sharp P.A.; Sharp, P (1 January 2005). "Phillip Sharp Discusses RNAi, Nobel Prizes and Entrepreneurial Science". Drug Discov Today 10 (1): 7–10. DOI:10.1016/S1359-6446(04)03329-X. PMID 15676292. 

• Lee K.B., Sharp P.A. (7 December 2004). "Transcription-dependent Polyubiquitination of RNA Polymerase II Requires Lysine 63 of Ubiquitin". Biochemistry 43 (48): 15223–9. DOI:10.1021/bi048719x. PMID 15568815. 

• Mansfield J.H., Harfe B.D., Nissen R., Obenauer J., Srineel J., Chaudhuri A., Farzan-Kashani R., Zuker M., Pasquinelli A.E., Ruvkun G., Sharp P.A., Tabin C.J., McManus M.T. (October 2004). "MicroRNA-responsive 'Sensor' Transgenes Uncover Hox-like and Other Developmentally Regulated Patterns of Vertebrate MicroRNA Expression". Nat. Genet. 36 (10): 1079–83. DOI:10.1038/ng1421. PMID 15361871. 

• Fairbrother W.G., Holste D., Burge C.B., Sharp P.A. (September 2004). "Single Nucleotide Polymorphism-based Validation of Exonic Splicing Enhancers". PLoS Biol. 2 (9): E268. DOI:10.1371/journal.pbio.0020268. PMC 514884. PMID 15340491. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514884. 

• Novina C.D., Sharp P.A. (July 8, 2004). "The RNAi Revolution". Nature 430 (6996): 161–4. DOI:10.1038/430161a. PMID 15241403. 

• Ventura A., Meissner A., Dillon C.P., McManus M., Sharp P.A., Van Parijs L., Jaenisch R., Jacks T. (July 13, 2004). "Cre-lox-regulated Conditional RNA Interference from Transgenes". Proc Natl Acad Sci U S A. 101 (28): 10380–5. DOI:10.1073/pnas.0403954101. PMC 478580. PMID 15240889. http://www.pnas.org/cgi/content/full/101/28/10380. 

Kaynakça

1. http://www.nobelprize.org/nobel_prizes/medicine/laureates/1993/sharp-autobio.html

Dış bağlantılar

• Autobiography Nobel sitesinden
• Sharp's Research at MIT
• The Phil Sharp Lab
• The Official Site of Louisa Gross Horwitz Prize